So the team concluded that Pias3 promotes rod cell development and suppresses cone cell development. Next they wanted to know if Pias3 works the same in eye cells as it does in other cells, through ...

Endoplasmic reticulum (ER) stress and Unfolded Protein Response (UPR) signaling promote the pathology of many human diseases. Loss-of-function variants of the UPR regulator Activating Transcription ...

Many neurons receive synapses in stereotypic proportions from converging but functionally distinct afferents. However, developmental mechanisms regulating synaptic convergence are not well understood.

Ever heard of conotoxins? They are bioactive peptides present in the venom of the predatory marine cone snails that are well known for their effective envenomation strategy. The conotoxins help these ...

A marine cone snail uses the "taser and tether" hunting strategy. Credit: Helena Safavi Scientists already know that the venom of cone snails, which prowl the ocean floor for a fish dinner, contains ...

Researchers at the Johns Hopkins University School of Medicine and Washington University School of Medicine have identified a key to eye development — a protein that regulates how the light-sensing ...