One-letter difference in our DNA determines whether BCG vaccine provides good protection against tuberculosis or not. Researchers have elucidated how that one letter difference affects the activation ...

DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...

RNA’s Surprising Role in DNA Repair New insights could lead to improved treatments for cancer and other diseases. Francesca Storici and her research team discovered a surprising role for RNA in DNA ...

This image depicts the chemical structure of cytosine. It shows a hexagonal ring with nitrogen atoms at positions 1 and 3, and a primary amine group attached to carbon 4. The two remaining positions ...

We’re celebrating 180 years of Scientific American. Explore our legacy of discovery and look ahead to the future. In 1957, just four years after Francis Crick and other scientists solved the riddle of ...

Fargo, ND, is probably better known for its blizzards, floods, and eponymous TV series than its biotechnological prowess. Yet for the past 25 years, Aldevron, a manufacturer of DNA, RNA, and proteins, ...

In a recent study in Nature Communications, researchers examined the adenosine-to-inosine (A-to-I) nucleoside editing of postmortem and live prefrontal cortical tissues. Researchers found that RNA ...

This image illustrates the chemical structure of a purine molecule, highlighting the numbering of the carbon and nitrogen atoms. The purine structure consists of a pyrimidine ring (positions 1 to 6) ...

Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages. A vital step in protein-coding gene expression is messenger RNA ...