Complement activation contributes to platelet destruction in immune thrombocytopenia (ITP). However, there has been very little data describing serum complement levels in ITP patients, and no data ...

Circulating cold-insoluble complexes, observed in 11 of 31 patients with systemic lupus erythematosus (SLE), consisted mainly of immunoglobulin G and the C′lq component of complement and did not ...

To investigate levels of components of the alternative pathway of complement, and of two activation products, ASP and Bb, in persons ranging in insulin resistance both fasting and following the ...

To clarify the association between certain immunologic factors and clinical activity in patients with systemic lupus erythematosus, 96 patients were studied. Those with antibodies to deoxyribonucleic ...

Please provide your email address to receive an email when new articles are posted on . Low complement levels prior to pregnancy are associated with an increased risk for adverse outcomes, including ...

Levels of C4d and C4d/C4 associate with clinical and histopathological treatment response in proliferative lupus nephritis. Complement activation markers, particularly C4d and the C4d/C4 ratio, are ...

Transplant-associated thrombotic microangiopathy (TA-TMA) is a fatal complication that can occur after an allogeneic hematopoietic stem cell transplantation (allo-HSCT). Study finds that despite ...

Changes to serum proteins could be behind the debilitating condition known as long COVID. The findings, published in the journal Science, could pave the way for diagnosing and treating the disease.

Basel, December 8, 2022 — Novartis today announced the Phase III APPOINT-PNH study (NCT04820530) of investigational oral monotherapy iptacopan in complement-inhibitor-naïve (including anti-C5 ...